As of today, CBD oil is a thoroughly tested substance. It exhibits the following properties and helps with the following diseases and more:
In this article, we will analyze several benefits of CBD oil. This article will additionally detail CBD oil as a treatment alternative, including a new research. Highlights of research on CBD oil benefits will be explained.
This article is based on an extensive guide provided by https://biomdplus.com/cbd-oil/major-benefits-of-cbd-oil/
We’re in the midst of a growing revolution. For the past few years, society has seen the battle between two sides of the on-going war with marijuana.
On one side, we’ve seen claim after claim of how the controversial plant has changed lives for the better, some going so far as to say that it’s saved them. There’re doctors on their side who are eagerly testing and trying to prove that these cases are true. On the other side of the battlefield are federal agencies, such as the Food and Drug Administration (FDA), who continue to put up one roadblock after another. At the center of this war is the chance to use marijuana as a regulated prescription drug. The ongoing war, however, is giving way too many are calling the “Marijuana Revolution.”
Below are the major benefits of CBD oil:
● works on inflammation and autoimmune diseases,
● is neuroprotective for degenerative diseases,
● relieves symptoms of multiple sclerosis,
● may potentially help with schizophrenia,
● reduces epileptic seizures,
● works on anxiety,
● relieves pain, especially chronic pain,
● is helpful for rheumatoid arthritis,
● relieves nausea and increases appetite,
● reduces the risk of diabetes,
● lowers the risk of developing heart disease,
● helps in fighting depression,
● is helpful with inflammatory bowel disease,
● protects against bacteria,
● protects the brain against serious diseases,
● positively impacts bone growth,
● relieves symptoms associated with movement disorders (dyskinesia),
● aids with insomnia,
● helps fight drug addictions (opioid anti-inflammatory drugs and cigarettes),
● soothes skin inflammation associated with psoriasis,
● and has a positive effect on acne.
Inflammation and autoimmune diseases
CBD is a promising drug in the fight against various inflammatory conditions, especially those associated with pain. It acts on the body’s cannabinoid system, reducing this response and balancing the immune system, and it protects the body against oxidative stress.
The human immune system is sensitive to cannabinoids produced by our bodies, as well as those from external sources. Autoimmune diseases and inflammation can get this internal cannabinoid system out of balance. This is a
CBD acts on immune cells, causing many anti-inflammatory and antioxidant reactions:
CBD silences the Th1 arm of the immune system and causes the Th2 arm to take over. In CBD studies, it reduced Th1 (IL-6 and TNF-alpha) and Th2 (IL-4, IL-5, IL-13) responses in rats with asthma, as well as lowering inflammation and pain in mice. The production of inflammatory substances in immune cells also decreased (Th1: TNF-alpha, IFN-gamma, and IL-6; Th2: IL-4 and IL-8).
CBD can help stop Th17 dominance, which means it can produce positive effects in some of the Th17-dominant autoimmune diseases (e.g., Hashimoto’s). CBD also changes neutrophils into their anti-inflammatory state, and it reduces other inflammatory, immunological products (macrophage inflammatory protein-1).
CBD protects brain cells by reducing the effects of toxic substances and oxidative stress in brain cells. This property can be helpful when treating people for strokes or other forms of brain damage.
In a small study, five patients with movement disorders received 100 to 600 mg of CBD daily for six weeks. The results show that CBD reduced uncontrolled muscle vibration among these patients, and higher doses had an even more substantial effect.
Study on CBD and multiple sclerosis
A combination of CBD and THC alleviate muscle spasms in patients with multiple sclerosis, part of a study with 219 participants. Reference: https://www.ncbi.nlm.nih.gov/pubmed/27160412
In a study where animals were tested, CBD protected them from brain damage (reducing beta-amyloid toxicity), which could potentially help Alzheimer’s and Parkinson’s disease in the future. Administering CBD was also able to reverse poor cognitive function in animals with Alzheimer’s disease and protect the brain from the effects of stroke and reduced blood flow.
It is worth noting that CBD is a more powerful antioxidant than either vitamin C (ascorbic acid) or vitamin E (α-tocopherol) in human cells. Due to its anti-inflammatory
Relief for multiple sclerosis symptoms
Cannabinoids can relieve symptoms of multiple sclerosis (MS). In the study with 66 patients with multiple sclerosis and chronic pain, the combination of CBD and THC reduced pain
In another study on 50 patients with MS, the combination of CBD and THC slightly reduced muscle tone and improved sleep quality. The study also showed that lower doses had a weaker effect. It follows that some patients with multiple sclerosis may need higher doses to feel relief from the disease.
Unlike THC, CBD may be beneficial in preventing psychosis and reducing the symptoms of schizophrenia. While psychoactive THC in cannabis seems to trigger psychotic episodes, especially in people with schizophrenia, CBD has the opposite effect, reducing the number of these episodes. More and more research points to CBD as a natural alternative to antipsychotic drugs that has far fewer side effects. People who experience psychosis may produce too much or too little of the cannabinoids (from overactive dopamine receptors). CBD is a milder cannabinoid than internal cannabinoids, and it helps restore their balance in the brain. CBD also helps reduce inflammation, which often increases in schizophrenia. THC is a stronger cannabinoid than internal cannabinoids (anandamide and 2-AG)
and therefore, it may potentially cause psychosis.
In 42 patients with acute schizophrenia, CBD, administered in doses of up to 800 mg daily, improved all symptoms after 4 weeks. The cannabinoid worked just as well as the strong antipsychotic drug (amisulpride) but was better tolerated by patients. Interestingly, by blocking FAAH, CBD also reduced the breakdown of anandamide (an exogenous cannabinoid), which was associated with beneficial effects.
CBD can help reduce seizures in people with drug-resistant epilepsy. Participants in a three-month observational study included 23 children and young adults (ages 3-26) with refractory epilepsy. It turned out that purified 98% oil-based CBD extract reduced the number of seizures by half in 39% of participants. The maximum dose used was 25 mg/kg per day, the equivalent of 1750 mg per day for a person weighing 155 pounds.
In another study, CBD also reduced the number of seizures among 214 children and adults with epilepsy. CBD supplementation was safe even at the maximum dose, which was twice as high as in the previous study (50 mg/kg per day). In one study, parents of children suffering from treatment-resistant epilepsy
In another study with 15 epilepsy patients who were unresponsive to medications, 200-300 mg of cannabidiol daily for 4.5 months reduced the number of seizures.
In a brain imaging study, a single 400 mg dose of CBD reduced anxiety in 10 people with seasonal affective disorder (SAD) works by reducing blood flow to part of the limbic system, which is often overactive in this type of disorder. The cannabinoid increased blood flow to another region that is important for cognition and motivation (the posterior cortex). Another study
It appears that, with more research, the benefits of CBD may extend to individuals with different types of anxiety including panic attacks.
Many studies suggest that cannabinoids may be a new class of “painkillers,” helping millions of people suffering from chronic pain. We have cannabinoid receptors throughout our bodies, but the CB1 type is very densely scattered along pathways responsible for brain, spine, and nerve pain. The second type, CB2, is more important for the immune system and acts on inflammation. Therefore, our internal cannabinoids and CBD can act on both of these pathways and balance pain and inflammation.
In an extensive analysis of 766 participants, cannabinoids strongly and safely reduced various types of chronic pain (pain from neuropathy, arthritis, fibromyalgia, HIV, and multiple sclerosis).
Another study with nearly 2,000 participants showed that the benefits of using cannabis-based drugs to fight pain outweigh any risks.
Moreover, the combination of CBD and THC reduced pain in several studies of patients with multiple sclerosis and chronic pain (66 and 189 participants, respectively). CBD was
The combination of CBD and THC offers promising results for postoperative and chronic pain, as well as pain related to cancer, rheumatoid arthritis, and neuropathy. However, it should be noted that by using only CBD, we still see benefits in comparison to synthetic cannabinoids and even to using it with THC because it is not a psychoactive substance. Many people want to avoid THC’s potential side-effects of paranoia and drowsiness.
CBD reduces pain in a different way than opioids do, though both substances alleviate it. The study showed that CBD did not affect the opioid pathways in mice. However, CBD reduced both chronic inflammation and neuropathic pain in rodents. Significantly, neither CBD nor THC appears to cause a long-term increase in tolerance (after two years), unlike opioids and most other painkillers, which require higher and higher doses to continue to work.
As natural anti-inflammatory agents and antioxidants, cannabinoids can relieve joint pain and swelling. They could presumably also help reduce joint damage and improve inflammatory diseases such as rheumatoid arthritis. The combination of CBD and THC reduced the symptoms of arthritis (including pain) in patients with rheumatoid arthritis
Nausea relief and increased appetite
THC is a drug approved for treating nausea and vomiting (dronabinol) in humans. As for CBD, clinical evidence for these effects is limited. However, a study in rats showed that CBD reduced their nausea and vomiting.
Typically, CBD does reduce nausea and vomiting caused by taking toxic drugs (in animal studies). However, research also shows that giving animals very high doses can lead to increased nausea or loss of mitigating effects.
For cancer patients, a balanced combination of THC and CBD may be the best option for increasing appetite and soothing nausea. A high dose of THC is usually too strong, and CBD can help alleviate psychotropic effects without reducing appetite stimulation.
Though it is known that using cannabis increases appetite and calorie intake, paradoxically, research shows a lower BMI, less obesity, and a reduced risk of diabetes.
An observational study included a group of 4,657 adult men and women who used marijuana in the past and present. It turned out that they had lower fasting glucose and insulin levels (by 16%), smaller waist circumferences, lower BMI and insulin resistance (by 18%), and higher HDL levels. Since all of these factors are associated with diabetes, marijuana appears capable of reducing the risk of this disease.
In research, CBD prevented diabetes in young mice prone to this condition. Only 30% of CBD-treated mice had diabetes, compared to 86% of untreated mice.
A study on mice shows that CBD can prevent and delay the destruction of insulin-producing cells in the pancreas. It can also reduce the number of inflammatory cytokines in diabetic mice by transferring the Th1 to Th2 immune response. For humans, this would be particularly important for type I diabetes, which has a strong autoimmune basis.
Among people suffering from chronic pain, cannabis use generally reduces the usage of opioid analgesics. There are no safe, effective treatments for the growing number of people suffering from opioid-related disorders. CBD is a promising, safe alternative. It turns out that CBD can interfere with the brain’s reward system in response to opioids, morphine, and heroin.
Studies suggest that inhaling CBD can help reduce or stop smoking altogether. In a pilot study of 24 smokers, cannabidiol reduced the number of cigarettes smoked by about 40% without increasing the appetite for nicotine.
Acne and psoriasis
In a tissue study on human skin, CBD applied to the skin reduces the production of serum and the number of sebaceous glands. The oil also has an anti-inflammatory effect, which is obviously beneficial for acne. Perhaps in the future, there will be more research on these properties of cannabidiol and more care products containing it.
CBD reduces the excessive division of skin cells (keratinocytes), which may be beneficial for psoriasis.
Side effects and safety
CBD is generally well-tolerated, and it is safe at high doses and for long-term use in humans.
CBD reduced the activity of T and B lymphocytes, which may increase the risk of infection and worsen HIV in those with the condition, and may have an impact on tumor growth and metastasis, as well as on asthma.
Cannabidiol may reduce the activity of liver enzymes called cytochrome P450, which is responsible for metabolizing over 60% of prescribed drugs.
CBD can also cause mild lowering of blood pressure, dry mouth, dizziness, and sedation. In combination with THC, CBD
CBD dosage may vary, but it usually ranges from 100 mg to even 3 g per day, depending on the target health problem.
For protecting the brain (e.g., Alzheimer’s disease), reducing inflammation, and addressing muscle spasms (multiple sclerosis), doses of 100 to 600 mg of CBD have been used in clinical trials. In some studies, patients took as much CBD oil as they needed to experience a reduction in pain or relief of muscle tone.
A dose of up to 800 mg per day was used to treat psychosis and schizophrenia.